SLU-PP-332
An oral exercise-mimic that switches on the same fat-burning program a run does, in mice. No human data; sublingual, start at 1 mg.
What it is
SLU-PP-332 is for the experimenter who already trains and wants to see whether an exercise-mimetic adds endurance and fat burning on top, knowing it has never been given to a person in a study. It is a small molecule, taken by mouth, and the honest version is: interesting mouse data, a dose range nobody agrees on, and no safety record.
The people who try it are endurance and metabolic tinkerers who have already run MOTS-c and want the next thing, and people chasing fat oxidation during a cut who do not want a stimulant. It is the wrong choice for anyone who wants a proven result, anyone with a heart condition, and anyone who is not training, since the entire point is to amplify the exercise signal and there is nothing to amplify on the couch.
What people describe, when they describe anything, is that cardio feels easier and fat loss on a cut runs a little faster, usually noticed around week two to three. Some feel warmer or slightly wired in the first hour. A lot of people feel nothing, especially at 1 mg, and that is a legitimate result given how little is known about what dose a human needs. Good looks like more minutes at the same effort, not a different body. It will not do anything you can measure at rest, and it will not replace the training it is supposed to mimic.
The dose range is a mess, and that is the honest state of it: some people report results at about 1 mg a day, others take 20 to 60 mg a day from larger tablets, and nobody has data to say which is right. Start at 1 mg once a day for two weeks, sublingual (dissolved under the tongue), because reconstituting it for injection is difficult and most people do not bother. Only go up if nothing has happened and you are tolerating it; move in steps, not leaps. Take it before training and run it alone, with no stimulants or other metabolic compounds, so you know what it did. Run it 4 to 12 weeks at 1 mg, or about 4 weeks if you have gone up into the 20 to 60 mg range, then stop and see what held before you decide on another run. The mistake is reading a mouse dose per kilogram, scaling it to your bodyweight and taking it; that is where the 60 mg numbers come from.
It activates the estrogen-related receptors (ERR), which exercise switches on to build mitochondria and burn fat. In mice, it increased running endurance, raised fat oxidation and improved metabolic markers, including in obese animals, using daily injections. There are no human studies at all: no pharmacokinetics, no safety data, no dose-finding. So this is one of the few compounds here that is genuinely preclinical, and it should be run as such.
If you want the same metabolic lane with some human signal, MOTS-c is the better-grounded choice and 5-Amino-1MQ is the other feel-nothing add-on. If you want fat loss you can count on, a GLP-1 class drug. SLU-PP-332 is for people who want to be early, and who accept that early means unknown.
What people use it for
Endurance and fat burning
Early daysMice given SLU-PP-332 ran longer and further, burned more fat, and showed more oxidative muscle fibers, mimicking an endurance-training adaptation. The studies used injections, not tablets, and the doses were large per kilogram. In people the effect is unmeasured.
Obesity and metabolism
Early daysIn diet-induced obese mice it reduced fat gain and improved glucose handling without changing food intake, which is the reason it is sold as a fat-loss compound. No human has been studied, so whether any of this survives oral dosing at the amounts people use is unknown.
Human use
Early daysThere is no published human trial, pharmacokinetic study or safety data. Everything about human dosing is inference and forum reports. That is the single most important thing to know about it.
How it works
- Studied as an "exercise mimetic" for endurance and fat burning
- Very new and experimental
- Animal research only, no human data yet
- Treat as early-stage; the safety picture is unknown
How people use it
Safety, in brief
Things people sometimes notice
- Nothing noticeable, especially at 1 mg
- Feeling warm or slightly wired in the first hour
- Mild stomach upset from the tablet
The full picture — stop signs and who should talk to a doctor first — is on the dosing guide.
Sources
The labels and studies behind this page. Each link opens the original on PubMed, DailyMed or ClinicalTrials.gov.