Survodutide dosage and reconstitution
A weekly weight-loss shot in trials that adds a liver-fat-burning glucagon arm to the GLP-1 effect. About 16 percent off at 76 weeks.
Staying safe
Things people sometimes notice
- Nausea, worst in the week after each dose step
- Vomiting or diarrhoea at the higher steps
- Early fullness and a flat appetite
- A resting heart rate a few beats higher than your baseline
Stop and get help if (trouble breathing or swelling: call 911)
- Vomiting you cannot keep fluids through, with dizziness or dark urine (dehydration)
- Severe, constant belly pain that may spread to your back (possible pancreatitis)
- A racing or irregular heartbeat, or a resting rate that stays well above your normal
- Rash, swelling of the face or lips, or trouble breathing (an allergic reaction)
Talk to your doctor first, especially if
- You have any heart rhythm problem or heart disease; the glucagon arm raises heart rate and that has not been tested at scale
- You or your family have had medullary thyroid cancer or MEN 2, a class-wide GLP-1 warning
- You have had pancreatitis or gallbladder disease
- You take insulin or a sulfonylurea, since those doses need lowering to avoid low blood sugar
- You have liver disease and plan to use it for that: liver enzymes and imaging before and during are how you know it is working
Mixing it
In clinical trials survodutide is a once-weekly subcutaneous injection that is stepped up slowly to limit nausea. There is no FDA-reviewed label or supervised dosing for any gray-market product, so amounts and preparation outside a trial are not validated. Use the calculator for your exact vial if you have a reconstituted powder.
Let the vial reach room temperature and clean the top with an alcohol swab.
Add bacteriostatic water per your vial size and add it slowly down the side.
Swirl gently until dissolved. Do not shake.
Start low and step up slowly over weeks, since the GI side effects track the dose.
Keep refrigerated and use within a few weeks once mixed.