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Skin & HairHigher Risk

Melanotan I dosage and reconstitution

A tan with far less sun, from the gentler of the two melanotans. Real human data, and a mole-watching habit you have to respect.

UnderstandWhat it isApplyHow to use it

Staying safe

Things people sometimes notice

  • Nausea for an hour or two after the first few doses, worse at higher tiers
  • Facial flushing and a warm feeling shortly after injecting
  • Freckles and moles darkening within the first weeks, and new pigmented spots appearing
  • Less appetite for some people
  • Tiredness the evening of a dose, early on

Stop and get help if (trouble breathing or swelling: call 911)

  • A mole that changes shape, grows, develops an irregular edge or more than one color, or starts to itch or bleed; see a dermatologist before any more doses
  • Nausea or dizziness that does not ease after dropping back to 0.5 mg
  • Hives, swelling of the face or lips, or trouble breathing
  • Darkening that is patchy and uneven on the face, which can be melasma starting

Talk to your doctor first, especially if

  • You have had melanoma or non-melanoma skin cancer, have many or atypical moles, or have a parent or sibling with melanoma; get a skin check first and expect to be told no
  • You have melasma or are prone to it, since a melanocortin agonist can make it worse
  • You have high blood pressure or heart disease; Melanotan I is gentler than II on this, but blood pressure effects of the class are real
  • You are pregnant, nursing or trying to be; not studied for this

Mixing it

Here is the math for a 10 mg vial mixed with 1 ml of bacteriostatic water, taking a 0.5 mg dose.

Bring the vial to room temperature and clean the top.

Add 1 ml of bacteriostatic water slowly.

Swirl gently, do not shake.

Start with a low dose to gauge how you respond.

Store in the fridge. Use within about 3 to 4 weeks once mixed.

The short version

What it isA tan with far less sun, from the gentler of the two melanotans. Real human data, and a mole-watching habit you have to respect.
EvidenceAnimal 3/5 · Human 3/5 · Not approved
Want the background?What it is and the research
This is education, not medical advice. Doses shown are the patterns people commonly follow, not a prescription. Talk with a doctor before starting, especially if you take other medicines or have a health condition.
© 2026 PeptideHelp. This platform is for educational purposes only.
Melanotan I dosage, reconstitution & schedule · PeptideHelp