FOXO4-DRI dosage and reconstitution
A cell-killing anti-aging peptide that clears worn-out 'zombie' cells. One famous mouse study, zero human data, nothing you can feel.
Staying safe
Things people sometimes notice
- A day or two of fatigue or feeling run-down after dosing
- Muscle or joint soreness around dosing days
- Redness or a small lump at the injection site
Stop and get help if (trouble breathing or swelling: call 911)
- Hives, swelling of the face or lips, or trouble breathing
- A fever, swollen lymph nodes or an inflamed area that does not settle in a few days
- A wound or surgical site that stops healing or opens up; senescent cells are part of normal repair and you may have cleared the ones doing the work
Talk to your doctor first, especially if
- You have active cancer or a cancer history. The peptide acts on the p53 pathway and nobody knows what clearing senescent cells does to a tumor's neighborhood in a person
- You had surgery, a fracture or a significant wound in the last couple of months; healing tissue uses senescent cells on purpose
- You are immunosuppressed or have kidney or liver disease, since dead cells have to be cleared and nobody has measured that load in humans
- You are pregnant, nursing or trying to be; no data
Mixing it
FOXO4-DRI comes as a powder reconstituted with bacteriostatic water for subcutaneous injection. It is used in short 'pulses' rather than daily, mirroring how senolytics were dosed in animals. There is no validated human protocol, so amounts are community-reported and approximate.
Bring the vial to room temperature and wipe the top with an alcohol swab.
Add 1 ml of bacteriostatic water slowly down the side of the glass, not onto the powder. Then 10 units on an insulin syringe is 1 mg.
Swirl gently until dissolved; do not shake.
Use as a short pulse (three doses, every other day), then 4 to 8 weeks off, not an ongoing daily injection.
Store reconstituted product in the fridge and keep any trial short given the lack of safety data.